Marc C. Deller, D.Phil.
marcdeller.com eloratherapeutics.com marc@marcdeller.com GitHub DOI 10.5281/zenodo.21807353 
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PETase ANnotation and Triage System

Nature's solution to a human-made problem, and structural learnings from Nature

PANTS-10eadec83602

Human gut 202 aa · assembly ERZ24772404_FASTA_predicted_cds · contig ERZ24772404.68275-NODE-68283-length-701-cov-1.552632_1

Retrieval

E-value2.00e-10
Bitscore27.9
Identity to nearest0.336
Nearest characterisedEC:A0ABN3T5D2

Structure

Methodesmfold
Mean pLDDT91.4
RMSD to IsPETase9.78 Å
Aligned fraction0.177

Aligned fraction is a length-normalised gemmi superposition statistic, not a true TM-score.

Active site

TriadSNone/DNone/HNone
Ser–HisNone Å
His–AspNone Å
Cleft widthNone Å
Cleft depthNone Å

Aromatic clamp:

Structure, superposed on IsPETase

Catalytic triad drawn as ball-and-stick from the measured residues.

Sequence

LASWGCIVLGNEDPGTFSGDSADATLSWLLEENENPDSVLYQKVDADCLGLSGHSQGGVGVFNAISEQPNGGLYTCAVSLSPTQEDLAAALNIPYDPSKTVIHTLALAGTNSDVITPEGMESLYNKLGGPKAMALRAGTDHGQMLYSGDGYATAWFLYWLKGDKEAGIAFWGESPELARNPFWQQVQISGNGGQEPPRDMGC