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PETase ANnotation and Triage System

Nature's solution to a human-made health problem

Superposed structures

Every structure was aligned onto IsPETase (PDB 6EQE) when it was written, so these overlay directly and the browser aligns nothing. Catalytic triads are drawn from the residues the geometry stage measured, not from positions inferred by an alignment. IsPETase and FAST-PETase are shown by default: a candidate's geometry only means something beside a known enzyme, and one reference cannot show how far a working engineered variant has already moved from the wild type.

Reference enzymes · coordinate source

Candidates · mean pLDDT

Sequences one per selected structure

catalytic triad   substitution against the lineage wild type  · triad positions are labelled; hover any residue for its number. Click one to select it in the viewer, or click a residue in the viewer to find it here.

Nothing selected.