PANTS-3899eec78da2
Human gut 414 aa · assembly ERZ4560700_FASTA_predicted_cds · contig ERZ4560700.59362-Hadza-MoBio-hadza-E-H-E-1-1719--NODE-59362-length-2742-cov-32.716323_1
Retrieval
| E-value | 5.30e-12 |
| Bitscore | 33.1 |
| Identity to nearest | 0.256 |
| Nearest characterised | EC:A0ABW1NJ96 |
Structure
| Method | esmfold |
| Mean pLDDT | 90.3 |
| RMSD to IsPETase | 20.01 Å |
| Aligned fraction | 0.234 |
Aligned fraction is a length-normalised gemmi superposition statistic, not a true TM-score.
Active site
| Triad | S311/D361/H393 |
| Ser–His | 2.85 Å |
| His–Asp | 3.11 Å |
| Cleft width | 16.0 Å |
| Cleft depth | 4.42 Å |
Aromatic clamp: PHE252, PHE356, TRP280, TRP318, TRP401, TYR232
Structure, superposed on IsPETase
Catalytic triad drawn as ball-and-stick from the measured residues.
Sequence
MKRILNRILAMLLAAILLAAPVCAAQTGYTDVPENAWYEEAIRTVTEQGWMNGTGSGKFSPNATLTRAMLATVLWRMENCPAAAATGNFTDTVRGSWYDGGVSWCVAEGIFQGFPDGSFRPNDAITREQLALVFYRYADAKPTGTAAKVSVKNGCSWALDACAWANTEGLFTDALGTLDLCAPASRAEIAYWLAHFDVGTSVSSLTEGSFEGLGYLLYTPENAEKNMPLLVYLHGSHGKGSDLSVLTTTDGFPQYLADGLLGEVPAYVLIPQLPANEKGWLSSADTVMALIDTICEEKTIDRSRIALTGHSMGGTGTWDLALAYPDIFSRIAPMSGSIKTTSDTLKTLETMPIWAFVGEDDVVVKPESTETFIESVSEQNSDARVTVFEATDHVGVLQKAWLENGKALLNWLLQ