PANTS-4a3466447bfc
Human gut 291 aa · assembly ERZ24772358_FASTA_predicted_cds · contig ERZ24772358.39277-NODE-39282-length-1239-cov-2.709459_2
Retrieval
| E-value | 5.80e-16 |
| Bitscore | 46.1 |
| Identity to nearest | 0.264 |
| Nearest characterised | EC:A0A852TYE9 |
Structure
| Method | esmfold |
| Mean pLDDT | 89.4 |
| RMSD to IsPETase | 8.36 Å |
| Aligned fraction | 0.189 |
Aligned fraction is a length-normalised gemmi superposition statistic, not a true TM-score.
Active site
| Triad | S131/D227/H259 |
| Ser–His | 3.18 Å |
| His–Asp | 3.22 Å |
| Cleft width | 22.59 Å |
| Cleft depth | 3.27 Å |
Aromatic clamp: PHE175, PHE232, PHE264, PHE265, TRP166, TRP56, TRP62, TYR135, TYR167, TYR177, TYR89, TYR97
Structure, superposed on IsPETase
Catalytic triad drawn as ball-and-stick from the measured residues.
Sequence
MKEVLKINVEKPQYVAITGITYAQVDSWYGHCRRDLKLDLIYPEDFSGKTYPCVVWICGGAWLRMDRSAHFAYLSKLAQSGFVVASVEYRTSNEGEYPMQIQDVKAAIRYLRAHADRYRIDAEYFGVTGESAGGYLTCMAALDEDVSLDVGDYLEQSSKVQAACPWYPPTDTSKFQYQEAEQCAASPESLLLGFNVMKNPEKGYENSPVSKVTKEAPPFLIIHGTNDRTVPFSQSESLYESLEKNGCDVTFLALEGADHADLQFFQDEVWERMISFFKEKLTRICRENIKS