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PETase ANnotation and Triage System

Nature's solution to a human-made problem, and structural learnings from Nature

PANTS-84ed462a2f48

Human gut 287 aa · assembly ERZ4560750_FASTA_predicted_cds · contig ERZ4560750.9260-Hadza-MoBio-hadza-E-H-E-23-1730--NODE-9260-length-10386-cov-12.944029_5

Retrieval

E-value4.30e-09
Bitscore23.5
Identity to nearest0.283
Nearest characterisedEC:A0ABY6YXF2

Structure

Methodesmfold
Mean pLDDT86.0
RMSD to IsPETase13.48 Å
Aligned fraction0.215

Aligned fraction is a length-normalised gemmi superposition statistic, not a true TM-score.

Active site

TriadS138/D186/H220
Ser–His3.04 Å
His–Asp2.95 Å
Cleft width15.78 Å
Cleft depth4.29 Å

Aromatic clamp: PHE147, PHE66, TRP109, TYR142, TYR83

Structure, superposed on IsPETase

Catalytic triad drawn as ball-and-stick from the measured residues.

Sequence

MQNMKTLFLKIFCAVMLLLPMCSMTAFAQYDFLRPVKGEIPGGYDFWVYTPTDYYYSLESTPVIMFLHGASLCSKDMNRSRRYGPLDAIVRGRQIDALVIVPQNPGGAWNPDKLNDILEWTKHNYAMDSTRVYVLGMSLGGYGTMDFAAAYPEKIAAAMALCGGCSAKDKSGLGKLPLWIIHGTADRAVSVKQSQSVVKELQEKGNDTRLRFDWLKGASHGALARILYMRKTYEWLFSHNLAQPGRPVRPDITIDTSDMTKAYNDMKKGVPSPEIIFEKSIKEDDEY