PANTS-bca3c3c4cafb
Human gut 281 aa · assembly ERZ4560321_FASTA_predicted_cds · contig ERZ4560321.17148-Hadza-MoBio-hadza-E-H-G-21-1740--NODE-17148-length-7009-cov-59.195326_2
Retrieval
| E-value | 2.10e-09 |
| Bitscore | 24.6 |
| Identity to nearest | 0.224 |
| Nearest characterised | HGMP04 |
Structure
| Method | esmfold |
| Mean pLDDT | 85.7 |
| RMSD to IsPETase | 15.81 Å |
| Aligned fraction | 0.211 |
Aligned fraction is a length-normalised gemmi superposition statistic, not a true TM-score.
Active site
| Triad | S168/D225/H258 |
| Ser–His | 3.05 Å |
| His–Asp | 3.01 Å |
| Cleft width | 20.18 Å |
| Cleft depth | 2.72 Å |
Aromatic clamp: PHE104, PHE106, PHE122, PHE260, TRP109, TRP121, TYR133, TYR192, TYR76, TYR84
Structure, superposed on IsPETase
Catalytic triad drawn as ball-and-stick from the measured residues.
Sequence
MKKWIKAVLVGAGAFAVVAGIAAVIGIGHYVGFPKPAGEEKTGYRTEKLCVEYDGISLYGKALIPDGDGPFSTVLYAHGAESDYKADMTTLKSLAMSGVACYTFDFYGWTDRSTGPQGVHWFHDVPRGVDDSYEKKVLQQVEDLNAVIEAAKGWDFVDTSRLYLVGSSMGGATVATAAVTHSDDIRGIVLQYPAINLNPDAMVSGAPLDVNGYTGPVLILQGTKDVIVPMEMSQDLTAHYNTLRDDHAELILYEGQPHVFMGKYKVLAAKEIYRFLKEVAS