Marc C. Deller, D.Phil.
marcdeller.com eloratherapeutics.com marc@marcdeller.com GitHub DOI 10.5281/zenodo.21807353 
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PETase ANnotation and Triage System

Nature's solution to a human-made problem, and structural learnings from Nature

PANTS-c2067f8dae0a

Human gut 241 aa · assembly ERZ4560891_FASTA_predicted_cds · contig ERZ4560891.9842-Hadza-MoBio-C-REDO-D-10-1550--NODE-9842-length-2335-cov-2.506643_3

Retrieval

E-value6.60e-09
Bitscore22.9
Identity to nearest0.289
Nearest characterisedPLC:C0ZUA7

Structure

Methodesmfold
Mean pLDDT97.4
RMSD to IsPETase11.64 Å
Aligned fraction0.189

Aligned fraction is a length-normalised gemmi superposition statistic, not a true TM-score.

Active site

TriadSNone/DNone/HNone
Ser–HisNone Å
His–AspNone Å
Cleft widthNone Å
Cleft depthNone Å

Aromatic clamp:

Structure, superposed on IsPETase

Catalytic triad drawn as ball-and-stick from the measured residues.

Sequence

MKKKIIITISVILGIILGSSLVWSSKSYKPNELAIQALNSDKKIEVKNDKFISFTPKDKEVEKGFIFYPGAGVEPEAYAPICREIALKGYEVVIAKMPLNLAILSPNKADKIISSYNNIKTWAIGGHSLGGVMASKYASNHDDIKAVAFYASYPSNDELKDLDLEVLSLYGEKDGVLNKGNLAKSKENLPSDAKFIEIKGGNHSQFGDYGLQNGDEKASITEEKQFETTANYTIEVLDKIK