Marc C. Deller, D.Phil.
marcdeller.com eloratherapeutics.com marc@marcdeller.com GitHub DOI 10.5281/zenodo.21807353 
########     ###    ##    ## ########  ######  
##     ##   ## ##   ###   ##    ##    ##    ## 
##     ##  ##   ##  ####  ##    ##    ##       
########  ##     ## ## ## ##    ##     ######  
##        ######### ##  ####    ##          ## 
##        ##     ## ##   ###    ##    ##    ## 
##        ##     ## ##    ##    ##     ######

PETase ANnotation and Triage System

Nature's solution to a human-made health problem

PANTS-e275f7c69959

Human gut 289 aa · assembly ERZ4560700_FASTA_predicted_cds · contig ERZ4560700.42164-Hadza-MoBio-hadza-E-H-E-1-1719--NODE-42164-length-3692-cov-3.630705_2

Retrieval

E-value2.90e-07
Bitscore17.5
Identity to nearest0.243
Nearest characterisedEC:A0ABR9JL03

Structure

Methodesmfold
Mean pLDDT95.0
RMSD to IsPETase23.44 Å
Aligned fraction0.200

Aligned fraction is a length-normalised gemmi superposition statistic, not a true TM-score.

Active site

TriadSNone/DNone/HNone
Ser–HisNone Å
His–AspNone Å
Cleft widthNone Å
Cleft depthNone Å

Aromatic clamp:

Structure, superposed on IsPETase

Catalytic triad drawn as ball-and-stick from the measured residues.

Sequence

MKKKKAKSSSKNMYDTFSITMELERPLLYNEEDYTEKKREEERQNRVKSIKKALFVLLFVLTVFIIGFFIWLSNGYSLQSYDLKYLESNSKVEVKTDGDYTYFTPTNVNATKGFIFYPGERVDSSSYAKLCNMIASYGYKVVAVDMPFNYASFGENKADDVIKNNPEITKWVIGGDSLGGTVASNYAINNKNIEGIVFISSYPRENISELGFKVLSLWGSKDNVVDYKELINSKERLPKDTKYIEIEGANHSQFANYGTYSGDGEALISSDEQMDITVRNIVNFLYNIH