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PETase ANnotation and Triage System

Nature's solution to a human-made problem, and structural learnings from Nature

PANTS-ec9743320c0e

Human gut 290 aa · assembly ERZ4561272_FASTA_predicted_cds · contig ERZ4561272.317-Hadza-MoBio-hadza-A-D-F-2-1628--NODE-317-length-118123-cov-25.430959_116

Retrieval

E-value3.70e-09
Bitscore23.7
Identity to nearest0.290
Nearest characterisedEC:A0A8J3U475

Structure

Methodesmfold
Mean pLDDT89.7
RMSD to IsPETase20.86 Å
Aligned fraction0.181

Aligned fraction is a length-normalised gemmi superposition statistic, not a true TM-score.

Active site

TriadS184/D234/H266
Ser–His2.86 Å
His–Asp3.22 Å
Cleft width17.64 Å
Cleft depth4.42 Å

Aromatic clamp: PHE125, PHE229, PHE267, TRP153, TRP191, TYR105

Structure, superposed on IsPETase

Catalytic triad drawn as ball-and-stick from the measured residues.

Sequence

MKRTIVILLAVLMTATVITVFSGCGSGQTPNTEESTPKQRTEEITENTEIPETSEESTEDTKPEDKPAAASSFHACSIKTNSLGELKYWLYTPSDPTENMPLIVYLHGGSGKGDDLELITAVDGFPKYLRDGQLGDVRAYVIIPQLPSSQKGWANGAAAVYELIQVTVSKFGIYEKNISLTGHSMGGTGTWNLALSYPTLFARIAPLSGSVRVQPEYIEKLKNIPVWAFVGSVDTIVPPDSSMEFVAALKEAGGNAGITIFGDADHFTVPSLTYLDKDIDLISWLTDKAD